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Symbol
Name
ID

Htt
huntingtin
MGI:96067

Phenotype annotations related to nervous system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Hyposmia

Spasticity

Gliosis

Cerebellar atrophy

Neuronal loss in central nervous system

Gait ataxia

Bradykinesia

Chorea

Tremor

Depression

Anxiety

Panic attack

Hallucinations

Apathy

Reduced social reciprocity

Personality changes

Impulsivity

Agitation

Restless legs

Cognitive impairment

Dementia

Frontal lobe dementia

Short attention span

Insomnia

Hyperreflexia

Dyskinesia

Dystonia

Gait imbalance

Postural instability

Seizure

Abnormal autonomic nervous system physiology

Disease(s) Associated with HTT

Huntington's disease

Parkinson's disease

Mouse Phenotypes

nervous system phenotype

seizures

environmentally induced seizures

tonic-clonic seizures

microgliosis

abnormal brain morphology

abnormal cerebellum development

hydrocephaly

decreased brain size

abnormal brain ventricle morphology

enlarged lateral ventricles

enlarged third ventricle

abnormal lateral ventricle morphology

dilated lateral ventricle

abnormal cerebral aqueduct morphology

enlarged cerebral aqueduct

abnormal anterior commissure morphology

abnormal brain internal capsule morphology

abnormal midbrain morphology

abnormal forebrain morphology

abnormal globus pallidus morphology

abnormal striatum morphology

abnormal dorsal striatum morphology

abnormal medium spiny neuron morphology

abnormal ventral striatum morphology

abnormal subthalamic nucleus morphology

abnormal thalamus morphology

abnormal hippocampus morphology

absent hippocampal fimbria

abnormal telencephalon morphology

abnormal cerebral cortex morphology

decreased neocortex volume

abnormal primary motor cortex morphology

abnormal olfactory bulb morphology

abnormal cerebellum lobule morphology

abnormal postnatal subventricular zone morphology

brain atrophy

astrocytosis

abnormal oligodendrocyte morphology

decreased oligodendrocyte number

gliosis

abnormal nervous system development

abnormal embryonic/fetal subventricular zone morphology

abnormal lateral ganglionic eminence morphology

exencephaly

abnormal nervous system tract morphology

abnormal neuron morphology

decreased myelin sheath thickness

ectopic neuron

neuron degeneration

neuronal cytoplasmic inclusions

neuronal intranuclear inclusions

neurodegeneration

axon degeneration

abnormal nervous system physiology

abnormal oligodendrocyte physiology

abnormal myelination

dysmyelination

Availability

Mouse Genotype

Htt^tm1.1Tna/Htt^tm1.1Tna

Htt^tm1Detl/Htt^tm1Detl

*

Htt^tm1Mfc/Htt^tm1Mfc

Htt^tm2Detl/Htt^tm2Detl

*

Htt^tm2Mem/Htt^tm2Mem

*

Htt^tm3Mem/Htt^tm3Mem

*

Htt^tm4Mem/Htt^tm4Mem

Htt^tm5Mem/Htt^tm5Mem

*

Htt^tm7Mem/Htt^tm7Mem

Htt^tm1.1Pfs/Htt⁺

Htt^tm1.1Tna/Htt⁺

Htt^tm1Detl/Htt⁺

*

Htt^tm1Hay/Htt⁺

Htt^tm1Mem/Htt^tm6Mem

Htt^tm1Mem/Htt^tm7Mem

Htt^tm2.1Pfs/Htt⁺

Htt^tm2Detl/Htt⁺

*

Htt^tm4Mem/Htt⁺

Htt^tm5Detl/Htt⁺

Htt^tm5Mem/Htt⁺

Htt^tm6Mem/Htt^tm8Mem

*

Htt^tm1Mem/Htt^tm6Mem
Tg(CAG-cre/Esr1*)5Amc/0 (conditional)

Htt^tm1Szi/Htt^tm2Szi
Tg(Camk2a-cre)1Szi/0 (conditional)

Htt^tm1Szi/Htt^tm2Szi
Tg(Camk2a-cre)2Szi/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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